Signaling Systems in Oral Bacteria.

  title={Signaling Systems in Oral Bacteria.},
  author={Daniel P Miller and Richard J. Lamont},
  journal={Advances in experimental medicine and biology},
The supra- and subgingival plaque biofilm communities of plaque are composed of hundreds of different microbes. These communities are spatially and temporally structured, largely due to cell-cell communications that coordinate synergistic interactions, and intracellular signaling systems to sense changes in the surrounding environment. Homeostasis is maintained through metabolic communication, mutualistic cross-feeding, and cross-respiration. These nutritional symbioses can reciprocally… 
Roles of a Mast Cell–Specific Receptor MRGPRX2 in Host Defense and Inflammation
It is proposed that harnessing mast cells’ host defense and immunomodulatory properties via the activation of MRGPRX2 may lead to novel approaches for the treatment of drug-resistant bacterial infections and provide novel approaches to modulate these conditions.
Role of the RprY Response Regulator in P. gingivalis Community Development and Virulence.
Results establish the RprY response regulator as a component of the tyrosine phosphorylation regulon in P. gingivalis, which can independently control heterotypic community development through the Mfa1 fimbriae, and virulence through the T9SS.
Bacterial communication
Recent research on bacteria and other microorganisms has provided interesting insights into the nature of life, cooperation, evolution, individuality or species. In this paper, I focus on the
Identification and characterization of a UbK family kinase in Porphyromonas gingivalis which phosphorylates the RprY response regulator.
These results establish that P. gingivalis possesses an active UbK kinase in addition to a previously described Bacterial Tyrosine (BY) family kinase, and the response regulator RprY is identified as the first transcriptional regulator controlled by a UbK enzyme.
Visualized analysis of trends and hotspots in global oral microbiome research: A bibliometric study
Bibliometric studies on the scientific outputs of global oral microbiome research by Citespace software showed that periodontal disease, oral microbes, and dental plaque are research hotspots, and burst word analysis indicates that early childhood caries, squamous cell carcinoma, gut microbiome, Helicobacter pylori, Candida albicans, and dysbiosis are likely to become the research hotspot of the next era.
ISSN: 2595-6825
This work identified the new gene products not represented in the genome of Bifidobacterium breve DS15-17 using the raw reads of this organism and PAN2HGENE software was used to identify new gene Products.
Biodegradable engineered fiber scaffolds fabricated by electrospinning for periodontal tissue regeneration
This review provides an overview of the usage of electrospinning materials in treatments of periodontitis, in order to get to know the existing research situation and find treatment breakthroughs of the periodontal diseases.


Cyclic Dinucleotides in Oral Bacteria and in Oral Biofilms
The aim of this perspective article is to present available information on cyclic dinucleotides in oral bacteria and in oral biofilms, and technologies that can be used to detect cyclic Dinucleotide in oralBiofilms.
Periodontal Pathogens Produce Quorum Sensing Signal Molecules
ABSTRACT Different species of bacteria important in the composition of dental plaque were tested for production of extracellular autoinducer-like activities that stimulate the expression of the
Metabolic crosstalk regulates Porphyromonas gingivalis colonization and virulence during oral polymicrobial Infection
It is shown that streptococcal 4-aminobenzoate/para-amino benzoic acid (pABA) is required for maximal accumulation of Porphyromonas gingivalis in dual-species communities and established pABA as a critical cue produced by a partner species that enhances the fitness of P. gedivalis while diminishing its virulence.
Streptococcus gordonii utilizes several distinct gene functions to recruit Porphyromonas gingivalis into a mixed community
The results suggest that S.’gordonii governs the development of heterotypic oral biofilms through multiple genetic pathways, including biofilm architectural development.
Molecular Signaling Mechanisms of the Periopathogen, Treponema denticola
This review discusses existing literature focused on the genetic regulatory mechanisms of Treponema denticola and presents an overview of the possible roles of regulatory proteins identified through genome analyses, providing insight into the possible molecular mechanisms utilized by oral spirochetes to survive in the periodontal pocket and transition from a minor to a dominant organism.
Interspecies communication in Streptococcus gordonii-Veillonella atypica biofilms: signaling in flow conditions requires juxtaposition.
It is found that, during agar-plate coculture of these organisms, a signaling event occurs that results in increased expression of the S. gordonii alpha-amylase-encoding gene amyB, which provides evidence that, in open systems like those that predominate in natural biofilms, diffusible signals between species are designed to function over short distances.
Streptococcal Antagonism in Oral Biofilms: Streptococcus sanguinis and Streptococcus gordonii Interference with Streptococcus mutans
Three well-characterized and closely related oral species are studied to model clinically relevant interspecies antagonism and provide new insights into ecological factors that determine the outcome of competition between pioneer colonizing oral streptococci and the survival mechanisms of S. mutans in the oral biofilm.
Characterization of autoinducer 2 signal in Eikenella corrodens and its role in biofilm formation.
Data suggest that a LuxS-dependent signal plays a role in the biofilm formation by E. corrodens, a periodontal pathogen observed to secrete type 2 signaling molecules.
Metabolic Proximity in the Order of Colonization of a Microbial Community
A metabolic distance is defined between different species, based on the overlap in their enzyme content, and it is found that the tendency towards minimal metabolic distance may be counter-balanced by a propensity to pair organisms with maximal joint potential for synergistic interactions.
Role of Sodium in the RprY-Dependent Stress Response in Porphyromonas gingivalis
It is concluded that RprY is one of the regulators that controls stress responses in P. gingivalis, possibly by acting as a repressor since an rprY mutant showed a superstress reponse in sodium-depleted medium which is proposed inhibited growth.