Signaling Pathways in Cartilage Repair

  title={Signaling Pathways in Cartilage Repair},
  author={Erminia Mariani and Lia Pulsatelli and Andrea Facchini},
  booktitle={International journal of molecular sciences},
In adult healthy cartilage, chondrocytes are in a quiescent phase characterized by a fine balance between anabolic and catabolic activities. In ageing, degenerative joint diseases and traumatic injuries of cartilage, a loss of homeostatic conditions and an up-regulation of catabolic pathways occur. Since cartilage differentiation and maintenance of homeostasis are finely tuned by a complex network of signaling molecules and biophysical factors, shedding light on these mechanisms appears to be… CONTINUE READING
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