Signaling Pathways from the Endoplasmic Reticulum and Their Roles in Disease

  title={Signaling Pathways from the Endoplasmic Reticulum and Their Roles in Disease},
  author={Hisae Kadowaki and Hideki Nishitoh},
The endoplasmic reticulum (ER) is an organelle in which newly synthesized secretory and transmembrane proteins are assembled and folded into their correct tertiary structures. However, many of these ER proteins are misfolded as a result of various stimuli and gene mutations. The accumulation of misfolded proteins disrupts the function of the ER and induces ER stress. Eukaryotic cells possess a highly conserved signaling pathway, termed the unfolded protein response (UPR), to adapt and respond… CONTINUE READING


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