Signaling Networks Associated with AKT Activation in Non-Small Cell Lung Cancer (NSCLC): New Insights on the Role of Phosphatydil-Inositol-3 kinase

@inproceedings{Scrima2012SignalingNA,
  title={Signaling Networks Associated with AKT Activation in Non-Small Cell Lung Cancer (NSCLC): New Insights on the Role of Phosphatydil-Inositol-3 kinase},
  author={Marianna Scrima and Carmela De Marco and Fernanda Fabiani and Renato Franco and Giuseppe Pirozzi and Gaetano Rocco and Maria Ravo and Alessandro Weisz and Pietro Zoppoli and Michele Ceccarelli and Gerardo Botti and Donatella Malanga and Giuseppe Viglietto},
  booktitle={PloS one},
  year={2012}
}
Aberrant activation of PI3K/AKT signalling represents one of the most common molecular alterations in lung cancer, though the relative contribution of the single components of the cascade to the NSCLC development is still poorly defined. In this manuscript we have investigated the relationship between expression and genetic alterations of the components of the PI3K/AKT pathway [KRAS, the catalytic subunit of PI3K (p110α), PTEN, AKT1 and AKT2] and the activation of AKT in 107 surgically resected… CONTINUE READING