Signaling Network Model of Chromatin

@article{Schreiber2002SignalingNM,
  title={Signaling Network Model of Chromatin},
  author={S. Schreiber and B. Bernstein},
  journal={Cell},
  year={2002},
  volume={111},
  pages={771-778}
}
  • S. Schreiber, B. Bernstein
  • Published 2002
  • Biology, Medicine
  • Cell
  • We suggest that common principles underlie both cellular signaling networks and chromatin. To exemplify similarities, we focus on signaling complexes that form at membrane receptors and on nucleosomes. Multiple signal-transducing modifications on side chain residues of receptor tyrosine kinases (RTKs) and histone proteins are used to create docking sites that facilitate proximal relations of enzymes and their substrates. We argue that multiple histone modifications, like RTK modifications… CONTINUE READING
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