Signaling Network Model of Chromatin

  title={Signaling Network Model of Chromatin},
  author={S. Schreiber and B. Bernstein},
  • S. Schreiber, B. Bernstein
  • Published 2002
  • Biology, Medicine
  • Cell
  • We suggest that common principles underlie both cellular signaling networks and chromatin. To exemplify similarities, we focus on signaling complexes that form at membrane receptors and on nucleosomes. Multiple signal-transducing modifications on side chain residues of receptor tyrosine kinases (RTKs) and histone proteins are used to create docking sites that facilitate proximal relations of enzymes and their substrates. We argue that multiple histone modifications, like RTK modifications… CONTINUE READING
    372 Citations

    Figures and Topics from this paper

    Explore Further: Topics Discussed in This Paper

    Multivalent engagement of chromatin modifications by linked binding modules
    • 931
    Maintenance of chromatin states: an open-and-shut case.
    • 136
    Emerging roles for chromatin as a signal integration and storage platform
    • 217
    Chromatin Remodeling and Cancer
    • 104
    Collaborative spirit of histone deacetylases in regulating chromatin structure and gene expression.
    • 219
    The view from the biochemist
    • F. Fuks
    • Biology, Medicine
    • The European physical journal. E, Soft matter
    • 2006
    • 1
    Linking covalent histone modifications to epigenetics: the rigidity and plasticity of the marks.
    • 43
    • PDF


    The language of covalent histone modifications
    • 7,590
    • PDF
    Cellular Memory and the Histone Code
    • 1,097
    • Highly Influential
    Histone acetylation and an epigenetic code.
    • B. Turner
    • Biology, Medicine
    • BioEssays : news and reviews in molecular, cellular and developmental biology
    • 2000
    • 1,173
    • PDF
    Evolutionary Correlation Between Linker Histones and Microtubular Structures
    • 12
    Regulation of chromatin structure by site-specific histone H3 methyltransferases
    • 2,566
    • Highly Influential
    • PDF
    Acetylation: a regulatory modification to rival phosphorylation?
    • 1,124
    • PDF
    Deciphering the Transcriptional Histone Acetylation Code for a Human Gene
    • 663
    Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
    • 2,666
    Accounting for Specificity in Receptor Tyrosine Kinase Signaling
    • 36
    The tail does not always wag the dog
    • K. Luger
    • Biology, Medicine
    • Nature Genetics
    • 2002
    • 9