Signaling Microdomains Define the Specificity of Receptor-Mediated InsP3 Pathways in Neurons

@article{Delmas2002SignalingMD,
  title={Signaling Microdomains Define the Specificity of Receptor-Mediated InsP3 Pathways in Neurons},
  author={Patrick Delmas and Nicolas Wanaverbecq and Fe C. Abogadie and Mohini Mistry and David Brown},
  journal={Neuron},
  year={2002},
  volume={34},
  pages={209-220}
}
M(1) muscarinic (M(1)AChRs) and B(2) bradykinin (B(2)Rs) receptors are two PLCbeta-coupled receptors that mobilize Ca(2+) in nonexcitable cells. In many neurons, however, B(2)Rs but not M(1)AChRs mobilize intracellular Ca(2+). We have studied the membrane organization and dynamics underlying this coupling specificity by using Trp channels as biosensors for… CONTINUE READING