Signaling Metastasis by Induction of Hepatocyte Growth Factor Tissue Inhibitor of Metalloproteinases-1 Promotes Liver

Abstract

Balanced expression of proteases and their inhibitors is one prerequisite of tissue homeostasis. Metastatic spread of tumor cells through the organism depends on proteolytic activity and is the death determinant for cancer patients. Paradoxically, increased expression of tissue inhibitor of metalloproteinases1 (TIMP-1), a natural inhibitor of several… (More)

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