Signaling: cellular insights into the pathophysiology of bipolar disorder.

@article{Manji2000SignalingCI,
  title={Signaling: cellular insights into the pathophysiology of bipolar disorder.},
  author={Husseini K. Manji and Robert H. Lenox},
  journal={Biological psychiatry},
  year={2000},
  volume={48 6},
  pages={518-30}
}
Clinical studies over the years have provided evidence that monoamine signaling and hypothalamic-pituitary-adrenal axis disruption are integral to the pathophysiology of bipolar disorder. A full understanding of the pathophysiology from a molecular to a systems level must await the identification of the susceptibility and protective genes driving the underlying neurobiology of bipolar disorder. Furthermore, the complexity of the unique biology of this affective disorder, which includes the… CONTINUE READING

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