Signal transfer in passive dendrites with nonuniform membrane conductance.

@article{London1999SignalTI,
  title={Signal transfer in passive dendrites with nonuniform membrane conductance.},
  author={Michael London and Claude Meunier and Idan Segev},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 19},
  pages={8219-33}
}
In recent years it became clear that dendrites possess a host of ion channels that may be distributed nonuniformly over their membrane surface. In cortical pyramids, for example, it was demonstrated that the resting membrane conductance G(m)(x) is higher (the membrane is "leakier") at distal dendritic regions than at more proximal sites. How does this spatial nonuniformity in G(m)(x) affect the input-output function of the neuron? The present study aims at providing basic insights into this… CONTINUE READING