Signal transduction via the stem cell factor receptor/c-Kit

@article{Rnnstrand2004SignalTV,
  title={Signal transduction via the stem cell factor receptor/c-Kit},
  author={L. R{\"o}nnstrand},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2004},
  volume={61},
  pages={2535-2548}
}
  • L. Rönnstrand
  • Published 2004
  • Biology, Medicine
  • Cellular and Molecular Life Sciences CMLS
Abstract.Together with its ligand, stem cell factor, the receptor tyrosine kinase c-Kit is a key controlling receptor for a number of cell types, including hematopoietic stem cells, mast cells, melanocytes and germ cells. Gain-of-function mutations in c-Kit have been described in a number of human cancers, including testicular germinomas, acute myeloid leukemia and gastrointestinal stromal tumors.Stimulation of c-Kit by its ligand leads to dimerization of receptors, activation of its intrinsic… Expand
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