Signal transduction via the stem cell factor receptor/c-Kit
@article{Rnnstrand2004SignalTV, title={Signal transduction via the stem cell factor receptor/c-Kit}, author={L. R{\"o}nnstrand}, journal={Cellular and Molecular Life Sciences CMLS}, year={2004}, volume={61}, pages={2535-2548} }
Abstract.Together with its ligand, stem cell factor, the receptor tyrosine kinase c-Kit is a key controlling receptor for a number of cell types, including hematopoietic stem cells, mast cells, melanocytes and germ cells. Gain-of-function mutations in c-Kit have been described in a number of human cancers, including testicular germinomas, acute myeloid leukemia and gastrointestinal stromal tumors.Stimulation of c-Kit by its ligand leads to dimerization of receptors, activation of its intrinsic… Expand
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References
SHOWING 1-10 OF 170 REFERENCES
Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C.
- Biology, Medicine
- The Journal of biological chemistry
- 1994
- 103
Stat1 associates with c-kit and is activated in response to stem cell factor.
- Biology, Medicine
- The Biochemical journal
- 1997
- 105
Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding.
- Biology, Medicine
- Molecular and cellular biology
- 1994
- 105
- PDF
Signaling via Src family kinases is required for normal internalization of the receptor c-Kit.
- Biology, Medicine
- Blood
- 1999
- 82
Steel factor and c-kit protooncogene: genetic lessons in signal transduction.
- Biology, Medicine
- Critical reviews in oncogenesis
- 1994
- 108
c-kit ligand stimulates tyrosine phosphorylation of the c-Cbl protein in human hematopoietic cells.
- Biology, Medicine
- Leukemia
- 1996
- 45
The Kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136
- Biology, Medicine
- Current Biology
- 1998
- 364
Activation of the MAP kinase pathway by c-Kit is PI-3 kinase dependent in hematopoietic progenitor/stem cell lines.
- Biology, Medicine
- Blood
- 2004
- 85
Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant.
- Biology, Medicine
- Blood
- 2001
- 148