Signal transduction via platelet-derived growth factor receptors.


Platelet-derived growth factor (PDGF) exerts its stimulatory effects on cell growth and motility by binding to two related protein tyrosine kinase receptors. Ligand binding induces receptor dimerization and autophosphorylation, allowing binding and activation of cytoplasmic SH2-domain containing signal transduction molecules. Thereby, a number of different… (More)


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@article{Heldin1998SignalTV, title={Signal transduction via platelet-derived growth factor receptors.}, author={Carl-Henrik Heldin and Arne Ostman and L R{\"o}nnstrand}, journal={Biochimica et biophysica acta}, year={1998}, volume={1378 1}, pages={F79-113} }