Signal transduction through prion protein.

  title={Signal transduction through prion protein.},
  author={Sophie Mouillet-Richard and Myriam Ermonval and C Chebassier and J L Laplanche and Sylvain Lehmann and Jean Marie Launay and Odile Kellermann},
  volume={289 5486},
The cellular prion protein PrPc is a glycosylphosphatidylinositol-anchored cell-surface protein whose biological function is unclear. We used the murine 1C11 neuronal differentiation model to search for PrPc-dependent signal transduction through antibody-mediated cross-linking. A caveolin-1-dependent coupling of PrPc to the tyrosine kinase Fyn was observed. Clathrin might also contribute to this coupling. The ability of the 1C11 cell line to trigger PrPc-dependent Fyn activation was restricted… CONTINUE READING
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