Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans.

@article{Leberer1996SignalTT,
  title={Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans.},
  author={Ekkehard Leberer and Doreen Harcus and Ian D. Broadbent and Kelsey L. Clark and Daniel Dignard and Karl B Ziegelbauer and Annegret Schmidt and Neil A R Gow and Alistair J P Brown and David Y. Thomas},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 23},
  pages={13217-22}
}
The CST20 gene of Candida albicans was cloned by functional complementation of a deletion of the STE20 gene in Saccharomyces cerevisiae. CST20 encodes a homolog of the Ste20p/p65PAK family of protein kinases. Colonies of C. albicans cells deleted for CST20 revealed defects in the lateral formation of mycelia on synthetic solid "Spider" media. However, hyphal development was not impaired in some other media. A similar phenotype was caused by deletion of HST7, encoding a functional homolog of the… CONTINUE READING
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