Signal transduction pathways mediating neurotensin-stimulated interleukin-8 expression in human colonocytes.

@article{Zhao2001SignalTP,
  title={Signal transduction pathways mediating neurotensin-stimulated interleukin-8 expression in human colonocytes.},
  author={Dezheng Zhao and Andrew C. Keates and Sabina Kuhnt-Moore and Mary Pat Moyer and Ciaran Kelly and Charalabos Pothoulakis},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 48},
  pages={44464-71}
}
Neurotensin (NT), a neuropeptide released in the gastrointestinal tract in response to several stimuli, is involved in the pathophysiology of colonic inflammation. However, the molecular mechanism(s) mediating this proinflammatory response remains unclear. We found that NCM460, non-transformed human colonocytes, express a functional high affinity NT receptor that mediates NT-induced Erk activation. By using NCM460 cells stably transfected with NTR1, we show that NTR1 activation leads to… CONTINUE READING

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