Signal transduction pathways mediating CCK-induced gallbladder muscle contraction.

  title={Signal transduction pathways mediating CCK-induced gallbladder muscle contraction.},
  author={Peirong Yu and Qian Chen and Zouliang Xiao and Karen M Harnett and Piero Biancani and Jos{\'e} Behar},
  journal={The American journal of physiology},
  volume={275 2 Pt 1},
The signal transduction that mediates CCK-induced contraction of gallbladder muscle was investigated in the cat. Contraction was measured by scanning micrometry in single muscle cells isolated enzymatically with collagenase. Production of D-myo-inositol 1,4, 5-trisphosphate (IP3) and sn-1,2-diacylglycerol (DAG) was quantitated using HPLC and TLC, respectively. Protein kinase C (PKC) activity was determined by measuring the phosphorylation of a specific substrate peptide from myelin basic… CONTINUE READING


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