Signal transduction pathways involved in tumour necrosis factor secretion by Plasmodium falciparum-stimulated human monocytes.

@article{Picot1994SignalTP,
  title={Signal transduction pathways involved in tumour necrosis factor secretion by Plasmodium falciparum-stimulated human monocytes.},
  author={St{\'e}phane Picot and I Sheick and A Sylvi and A Donadille and Pierre Ambroise-Thomas},
  journal={Immunology},
  year={1994},
  volume={83 1},
  pages={70-4}
}
Tumour necrosis factor (TNF) plays a pivotal role in the induction of cerebral complications during Plasmodium falciparum malaria. TNF secretion by macrophages can be induced by lipopolysaccharide (LPS) and by P. falciparum antigens, but it is unclear whether similar mechanisms control the monokine expression in both cases. The signal transduction pathway… CONTINUE READING