Signal transduction pathways involved in enterohemorrhagic Escherichia coli-induced alterations in T84 epithelial permeability.

@article{Philpott1998SignalTP,
  title={Signal transduction pathways involved in enterohemorrhagic Escherichia coli-induced alterations in T84 epithelial permeability.},
  author={Dana J Philpott and D M McKay and W. Mak and Mary H. Perdue and Philip M. Sherman},
  journal={Infection and immunity},
  year={1998},
  volume={66 4},
  pages={1680-7}
}
Enterohemorrhagic Escherichia coli (EHEC) infection is associated with watery diarrhea and can lead to complications, including hemorrhagic colitis and the hemolytic-uremic syndrome. The mechanisms by which these organisms produce diarrheal disease remain to be elucidated. Changes in T84 epithelial cell electrophysiology were examined following EHEC infection. T84 cell monolayers infected with EHEC O157:H7 displayed a time-dependent decrease in transepithelial resistance. Increases in the… CONTINUE READING

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