Signal transduction pathways involved in proteolysis-inducing factor induced proteasome expression in murine myotubes

@article{Smith2003SignalTP,
  title={Signal transduction pathways involved in proteolysis-inducing factor induced proteasome expression in murine myotubes},
  author={Helen J. Smith and Michael John Tisdale},
  journal={British Journal of Cancer},
  year={2003},
  volume={89},
  pages={1783 - 1788}
}
The proteolysis-inducing factor (PIF) is produced by cachexia-inducing tumours and initiates protein catabolism in skeletal muscle. The potential signalling pathways linking the release of arachidonic acid (AA) from membrane phospholipids with increased expression of the ubiquitin–proteasome proteolytic pathway by PIF has been studied using C2C12 murine myotubes as a surrogate model of skeletal muscle. The induction of proteasome activity and protein degradation by PIF was blocked by quinacrine… CONTINUE READING