Signal transduction pathways involved in BCR-ABL transformation.

  title={Signal transduction pathways involved in BCR-ABL transformation.},
  author={Charles L Sawyers},
  journal={Bailliere's clinical haematology},
  volume={10 2},
BCR-ABL is an oncogenic fusion gene found in patients with chronic myelogenous leukaemia (CML) and acute lymphocytic leukaemia whose oncogenic potential has been demonstrated using in vitro and in vivo model systems. Current research efforts are focused on defining the mechanism by which BCR-ABL transforms cells, with a view toward applying insights from these studies to the treatment of CML patients. BCR-ABL contains tyrosine residues, an SH2 domain, an SH3 domain, and proline-rich sequences… CONTINUE READING