Signal transduction pathways in normal human monocytes stimulated by cytokines and mediators: comparative study with normal human neutrophils or transformed cells and the putative roles in functionality and cell biology.

@article{Yagisawa1999SignalTP,
  title={Signal transduction pathways in normal human monocytes stimulated by cytokines and mediators: comparative study with normal human neutrophils or transformed cells and the putative roles in functionality and cell biology.},
  author={Morimasa Yagisawa and Kumiko Saeki and Emiko Okuma and Toshio Kitamura and Seiichi Kitagawa and Hiroyuki Hirai and Yoshio Yazaki and Fumimaro Takaku and Akira Yuo},
  journal={Experimental hematology},
  year={1999},
  volume={27 6},
  pages={1063-76}
}
Granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin (IL) -3 induced tyrosine phosphorylation of 92-kDa protein in normal human monocytes. We identified this 92-kDa protein as STAT5, but not as STATs1, 3, and 6 nor c-fes and vav protooncogene products, and demonstrated its translocation to the nucleus, enhancement of specific DNA binding capacity, and potentiation of trancriptional activity by GM-CSF. N-formyl-methionyl-leucyl-phenylalanine (FMLP) and phorbol myristate… CONTINUE READING