Signal transduction pathways associated with ATP-induced proliferation of cell progenitors in the intact embryonic retina

@article{Nunes2007SignalTP,
  title={Signal transduction pathways associated with ATP-induced proliferation of cell progenitors in the intact embryonic retina},
  author={Patricia Helena Castro Nunes and Karin da Costa Calaza and Lidiane Martins Albuquerque and Lucianne Fragel-Madeira and Ana L{\'u}cia Marques Ventura},
  journal={International Journal of Developmental Neuroscience},
  year={2007},
  volume={25},
  pages={499-508}
}
ATP and ADP induce retinal cell proliferation through activation of PKC and extracellular signal-regulated kinases (ERKs). Here, we characterized the effect of purinergic agonists on the turnover of phosphoinositides and activation of ERKs during development of the chick embryo retina. When intact retinas were incubated with ATP, ADP or UTP, a dose-dependent accumulation of [(3)H]-phosphoinositides was observed (% of control, EC(50): 548+/-20.5%, 0.18 mM; 314+/-53.8%, 0.51 mM; 704+/-139.9%, 0… CONTINUE READING

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