Signal transduction pathways activated by RET oncoproteins in PC12 pheochromocytoma cells.

@article{Xing1998SignalTP,
  title={Signal transduction pathways activated by RET oncoproteins in PC12 pheochromocytoma cells.},
  author={Sixun Xing and T L Furminger and Q Tong and Sissy M. Jhiang},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 9},
  pages={4909-14}
}
Gene alterations in the ret proto-oncogene, which encodes a receptor tyrosine kinase, have been found to associate with several human diseases. In this study, we showed that induction of the vgf promoter activity is a good molecular indicator for RET activation in PC12 cells, a rat pheochromocytoma cell line. We demonstrated that all forms of RET oncoprotein, including RET chimeric oncoproteins found in human papillary thyroid carcinomas (RET/PTC) as well as RET oncoproteins found in patients… CONTINUE READING

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