Signal transduction pathway regulating prostaglandin EP3 receptor-induced neurite retraction: requirement for two different tyrosine kinases.

@article{Aoki1999SignalTP,
  title={Signal transduction pathway regulating prostaglandin EP3 receptor-induced neurite retraction: requirement for two different tyrosine kinases.},
  author={Junken Aoki and Hironori Katoh and Hirofumi Yasui and Yu Yamaguchi and Kazuhiro Nakamura and Hiroshi Hasegawa and Atsushi Ichikawa and Manabu Negishi},
  journal={The Biochemical journal},
  year={1999},
  volume={340 ( Pt 2)},
  pages={365-9}
}
We reported previously that activation of the prostaglandin E receptor EP3 subtype triggered neurite retraction through the small GTPase Rho-, and its target, RhoA-binding kinase alpha (ROKalpha)-, dependent pathway in EP3 receptor-expressing PC12 cells. Here we examined the involvement of tyrosine kinases in this pathway in nerve growth factor-differentiated PC12 cells. Tyrphostin A25, a tyrosine kinase inhibitor, blocked neurite retraction and cell rounding induced by activation of the EP3… CONTINUE READING

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