Signal transduction of nitric oxide donor-induced protection in hydrogen peroxide-mediated apoptosis in H9C2 cardiomyoblasts.

@article{Chae2001SignalTO,
  title={Signal transduction of nitric oxide donor-induced protection in hydrogen peroxide-mediated apoptosis in H9C2 cardiomyoblasts.},
  author={Hyun Jung Chae and Hyung Ryong Kim and Yong Guen Kwak and Jin Kyung Ko and Chan Joo and Soo Wan Chae},
  journal={Immunopharmacology and immunotoxicology},
  year={2001},
  volume={23 2},
  pages={
          187-204
        }
}
Nitric oxide (NO) attenuates hydrogen peroxide (H2O2)-mediated injury to H9C2 cardiomyoblasts. To examine the role of nitric oxide, cultured H9C2 cardiomyoblasts were treated with H2O2 for 2 h in the presence or absence of the NO donor, diethylamine nitric oxide (DEANO). DEANO (30 microM) attenuated H2O2-induced apoptosis in H9C2 cells. H2O2-exposed H9C2 cells resulted in apoptosis in a time-dependent manner estimated by DNA fragmentation assay, nuclear morphology stained with fluorescent dye… CONTINUE READING
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