Signal transduction molecules in gliomas of all grades

  title={Signal transduction molecules in gliomas of all grades},
  author={Ralph P Ermoian and Tania Betty Kaprealian and Kathleen R. Lamborn and Xiaodong Yang and Nannette Jelluma and Nils D. Arvold and Ruth Zeidman and Mitchel S. Berger and David Stokoe and Daphne Adele Haas-Kogan},
  journal={Journal of Neuro-Oncology},
Purpose To interrogate grade II, III, and IV gliomas and characterize the critical effectors within the PI3-kinase pathway upstream and downstream of mTOR. Experimental design Tissues from 87 patients who were treated at UCSF between 1990 and 2004 were analyzed. Twenty-eight grade II, 17 grade III glioma, 26 grade IV gliomas, and 16 non-tumor brain specimens were analyzed. Protein levels were assessed by immunoblots; RNA levels were determined by polymerase chain reaction amplification. To… CONTINUE READING

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