Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention

@article{Chang2003SignalTM,
  title={Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention},
  author={Fumin Chang and Linda S. Steelman and John T. Lee and John G. Shelton and Patrick Michael Navolanic and William L. Blalock and Richard A. Franklin and James A McCubrey},
  journal={Leukemia},
  year={2003},
  volume={17},
  pages={1263-1293}
}
The Ras/Raf/Mitogen-activated protein kinase/ERK kinase (MEK)/extracellular-signal-regulated kinase (ERK) cascade couples signals from cell surface receptors to transcription factors, which regulate gene expression. Depending upon the stimulus and cell type, this pathway can transmit signals, which result in the prevention or induction of apoptosis or cell cycle progression. Thus, it is an appropriate pathway to target for therapeutic intervention. This pathway becomes more complex daily, as… CONTINUE READING
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