Signal transduction in rheumatoid arthritis.

  title={Signal transduction in rheumatoid arthritis.},
  author={Susan E. Sweeney and Gary S. Firestein},
  journal={Current opinion in rheumatology},
  volume={16 3},
PURPOSE Signal transduction pathways are the intracellular mechanism by which cells respond and adapt to environmental stress. Understanding the critical networks in diseases like rheumatoid arthritis can potentially identify novel therapeutic targets. RECENT FINDINGS Dissecting the complex pathways involved in rheumatoid synovitis, including mitogen-activated protein kinases, NF-kB, tumor suppressors, Janus kinases, the signal transducer and activator of transcription, suppressors of… CONTINUE READING