Signal transduction in l-DOPA-induced dyskinesia: from receptor sensitization to abnormal gene expression

Abstract

A large number of signaling abnormalities have been implicated in the emergence and expression of l-DOPA-induced dyskinesia (LID). The primary cause for many of these changes is the development of sensitization at dopamine receptors located on striatal projection neurons (SPN). This initial priming, which is particularly evident at the level of dopamine D1… (More)
DOI: 10.1007/s00702-018-1847-7

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