Signal transduction in keratinocytes.

  title={Signal transduction in keratinocytes.},
  author={Vanyo Ivanov Mitev and L. P. -E. Miteva},
  journal={Experimental dermatology},
  volume={8 2},
Keratinocytes, a key cellular component both for homeostasis and pathophysiologic processes of the skin, secrete a number of cytokines and their proliferation and differentiation are stimulated by a variety of biological factors. The major mechanism by which cells (keratinocytes) respond to extracellular signals, is changing in protein phosphorylation. The protein phosphorylation is a consequence of the ligand/receptor binding which leads to activation of several transduction systems. In this… CONTINUE READING

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