Signal transduction in human tumor infiltrating lymphocytes.

  title={Signal transduction in human tumor infiltrating lymphocytes.},
  author={Maria Raffaella Zocchi and Andreina Poggi and Francesca Crosti and Stefania Tongiani and Claudio Rugarli},
  journal={Archivum immunologiae et therapiae experimentalis},
  volume={41 1},
In the present study we demonstrate that the CD28 activation pathway was functional in human tumor infiltrating lymphocytes (TIL), as it could induce a strong proliferation. On the other hand, a mitogenic combination of anti-CD2 monoclonal antibodies (MoAb) induced a slight proliferation of TIL isolated from lung but not from renal cell carcinoma (RCC). It is to note that CD28 triggering led to calcium mobilization, whereas stimulation via CD2 did not. Moreover, in most cases no synergistic… CONTINUE READING
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