Signal transduction in human monocytes: relationship between superoxide production and the level of kinase C in the membrane.

@article{CostaCasnellie1986SignalTI,
  title={Signal transduction in human monocytes: relationship between superoxide production and the level of kinase C in the membrane.},
  author={M R Costa-Casnellie and George B. Segel and Marshall A. Lichtman},
  journal={Journal of cellular physiology},
  year={1986},
  volume={129 3},
  pages={336-42}
}
Activation of monocytes and neutrophils results in an increased production of superoxide, an important cytotoxic compound. The previous finding that two agents that induce superoxide production cause opposite translocation of kinase C (Costa-Casnellie et al. [1985] Biochem. Biophys. Res. Commun., 133:1139-1144). led us to study the role of kinase C in superoxide production. In monocytes induction of superoxide production by 13-tetradecanoate phorbol acetate requires translocation of kinase C… CONTINUE READING