Signal transduction in cancer.

@article{Sever2015SignalTI,
  title={Signal transduction in cancer.},
  author={Richard Sever and Joan S. Brugge},
  journal={Cold Spring Harbor perspectives in medicine},
  year={2015},
  volume={5 4}
}
Cancer is driven by genetic and epigenetic alterations that allow cells to overproliferate and escape mechanisms that normally control their survival and migration. Many of these alterations map to signaling pathways that control cell growth and division, cell death, cell fate, and cell motility, and can be placed in the context of distortions of wider signaling networks that fuel cancer progression, such as changes in the tumor microenvironment, angiogenesis, and inflammation. Mutations that… CONTINUE READING

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