Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes.

@article{Standen2009SignalTC,
  title={Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes.},
  author={Claire L. Standen and Norman SJ Kennedy and Richard A Flavell and Roger J Davis},
  journal={Molecular and cellular biology},
  year={2009},
  volume={29 17},
  pages={
          4831-40
        }
}
Scaffold proteins have been established as important mediators of signal transduction specificity. The insulin receptor substrate (IRS) proteins represent a critical group of scaffold proteins that are required for signal transduction by the insulin receptor, including the activation of phosphatidylinositol 3 kinase. The c-Jun NH(2)-terminal kinase (JNK)-interacting proteins (JIPs) represent a different group of scaffold molecules that are implicated in the regulation of the JNK. These two… CONTINUE READING

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