• Corpus ID: 37644663

Signal transduction cascade shared by epidermal growth factor and platelet-derived growth factor is a major pathway for oncogenic transformation in NRK cells.

@article{Masuda1992SignalTC,
  title={Signal transduction cascade shared by epidermal growth factor and platelet-derived growth factor is a major pathway for oncogenic transformation in NRK cells.},
  author={A Masuda and Shinae Kizaka-Kondoh and H Miwatani and Yasuhiko Terada and Hiroshi Nojima and Hiroto Okayama},
  journal={The New biologist},
  year={1992},
  volume={4 5},
  pages={
          489-503
        }
}
We have isolated two recessive, mutually complementary NRK cell mutants that are refractory to transformation by epidermal growth factor (EGF) and transforming growth factor-beta. Both mutants are defective in a signal transduction cascade shared by EGF and platelet-derived growth factor (PDGF). Analysis of the mutants suggests that transformation of NRK cells by the v-fms, v-erbB, activated erbB-2, v-ras, v-fos, v-mos, v-fes, v-src, SV40 large T, polyomavirus middle T, and human papillomavirus… 

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