Signal transduction by transforming growth factor-β: A cooperative paradigm with extensive negative regulation.

@article{Engel1998SignalTB,
  title={Signal transduction by transforming growth factor-β: A cooperative paradigm with extensive negative regulation.},
  author={Michael Eugene Engel and Pran K Datta and Harold L. Moses},
  journal={Journal of cellular biochemistry},
  year={1998},
  volume={72 Suppl 30-31 S30-31},
  pages={111-122}
}
Transforming growth factor-β (TGF-β) represents an evolutionarily conserved family of secreted factors that mobilize a complex signaling network to control cell fate by regulating proliferation, differentiation, motility, adhesion, and apoptosis. TGF-β promotes the assembly of a cell surface receptor complex composed of type I (TβRI) and type II (TβRII) receptor serine/threonine kinases. In response to TGF-β binding, TβRII recruits and activates TβRI through phosphorylation of the regulatory GS… CONTINUE READING

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