Signal transduction by the receptors for thrombopoietin (c-mpL) and interleukin-3 in hematopoietic and nonhematopoietic cells.

@article{Morella1995SignalTB,
  title={Signal transduction by the receptors for thrombopoietin (c-mpL) and interleukin-3 in hematopoietic and nonhematopoietic cells.},
  author={K K Morella and Edward Bruno and Satoru Kumaki and Chung Fang Lai and Jianxin Fu and Hong Min Wang and Lesley Murray and Ronald M Hoffman and M S Timour and Laurence Benit},
  journal={Blood},
  year={1995},
  volume={86 2},
  pages={557-71}
}
Antisense oligonucleotide to the translation initiation sequence of human c-mpI reduced the proliferation of human CD34+ bone marrow cells in response to interleukin-3 (IL-3) alone or to the combination of IL-3 and thrombopoietin (TPO). To investigate the molecular basis for these cytokine interactions, we analyzed the relationship between the receptor subunits for IL-3 and TPO and determined whether both receptors activate identical signal transduction pathways. The function of the receptor… CONTINUE READING
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