Signal transduction by reactive oxygen species

  title={Signal transduction by reactive oxygen species},
  author={Toren Finkel},
  booktitle={The Journal of cell biology},
Although historically viewed as purely harmful, recent evidence suggests that reactive oxygen species (ROS) function as important physiological regulators of intracellular signaling pathways. The specific effects of ROS are modulated in large part through the covalent modification of specific cysteine residues found within redox-sensitive target proteins. Oxidation of these specific and reactive cysteine residues in turn can lead to the reversible modification of enzymatic activity. Emerging… CONTINUE READING
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