Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins.

@article{Kornberg1991SignalTB,
  title={Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins.},
  author={L J Kornberg and H. Shelton Earp and C. Heath Turner and C Prockop and Rudolph L Juliano},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 19},
  pages={8392-6}
}
The integrin family of cell adhesion receptors mediates many of the interactions between cells and the extracellular matrix. Because the extracellular matrix has profound influences on cell behavior, it seems likely that integrins transduce biochemical signals across the cell membrane. The nature of these putative signals has, thus far, remained elusive. Antibody-mediated clustering of integrin receptors was used to mimic the integrin clustering process that occurs during formation of adhesive… CONTINUE READING
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