Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95.

@article{Chinnaiyan1996SignalTB,
  title={Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95.},
  author={Arul M. Chinnaiyan and Karen O'Rourke and Geliang L Yu and Robert H. Lyons and Manish Garg and D Roxanne Duan and Lei Xing and Reiner Gentz and Jian Ni and Vishva M. Dixit},
  journal={Science},
  year={1996},
  volume={274 5289},
  pages={990-2}
}
Tumor necrosis factor receptor-1 (TNFR-1) and CD95 (also called Fas or APO-1) are cytokine receptors that engage the apoptosis pathway through a region of intracellular homology, designated the "death domain." Another death domain-containing member of the TNFR family, death receptor 3 (DR3), was identified and was shown to induce both apoptosis and activation of nuclear factor kappaB. Expression of DR3 appears to be restricted to tissues enriched in lymphocytes. DR3 signal transduction is… CONTINUE READING
Highly Influential
This paper has highly influenced 16 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
182 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 182 extracted citations

Similar Papers

Loading similar papers…