Signal transduction and regulation of melatonin synthesis in bovine pinealocytes: impact of adrenergic, peptidergic and cholinergic stimuli

@article{Schomerus2002SignalTA,
  title={Signal transduction and regulation of melatonin synthesis in bovine pinealocytes: impact of adrenergic, peptidergic and cholinergic stimuli},
  author={Christof Schomerus and Elke Laedtke and James Olcese and Joan L. Weller and David C. Klein and Horst-Werner Korf},
  journal={Cell and Tissue Research},
  year={2002},
  volume={309},
  pages={417-428}
}
Limited studies of the regulation of pineal melatonin biosynthesis in ungulates indicate that it differs considerably from that in rodents. Here we have investigated several signal transduction cascades and their impact on melatonin synthesis in bovine pinealocytes. Norepinephrine increased the intracellular calcium ion concentration ([Ca2+]i) via α1-adrenergic receptors. Activation of β-adrenergic receptors enhanced cAMP accumulation and rapidly elevated arylalkylamine N-acetyltransferase… CONTINUE READING
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