Signal transduction and regulation in smooth muscle

@article{Somlyo1994SignalTA,
  title={Signal transduction and regulation in smooth muscle},
  author={A. Somlyo},
  journal={Nature},
  year={1994},
  volume={372},
  pages={231-236}
}
Smooth muscle cells in the walls of many organs are vital for most bodily functions, and their abnormalities contribute to a range of diseases. Although based on a sliding-filament mechanism similar to that of striated muscles, contraction of smooth muscle is regulated by pharmacomechanical as well as by electromechanical coupling mechanisms. Recent studies have revealed previously unrecognized contractile regulatory processes, such as G-protein-coupled inhibition of myosin light-chain… Expand
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CHAPTER 31 – Vascular Smooth Muscle Contraction
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Studies from the past two decades that support the hypothesis that the regulated expression of MP subunits is a critical determinant of smooth muscle responses to constrictor and dilator signals are reviewed and highly regulated splicing of the regulatory subunit Mypt1 Exon 24 is proposed to tune sensitivity to NO/cGMP‐mediated relaxation. Expand
Regulation of smooth muscle actin-myosin interaction and force by calponin.
TLDR
Three physiological roles of calponin can be considered based on its in vitro functional properties: (i) maintenance of relaxation at resting [Ca2+]i, (ii) energy conservation during prolonged contractions, and (iii) Ca(2+)-independent contraction mediated by phosphorylation of calPonin by PKC epsilon, a Ca( 2+)- independent isoenzyme of PKC. Expand
Regulation of myosin phosphatase by a specific interaction with cGMP- dependent protein kinase Ialpha.
TLDR
Un Uncoupling of the cGKIalpha-MBS interaction prevents cGMP-dependent dephosphorylation of myosin light chain, demonstrating that this interaction is essential to the regulation of vascular smooth muscle cell tone. Expand
Myosin Light Chain Kinase Is Necessary for Tonic Airway Smooth Muscle Contraction*
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The regulation of smooth muscle contractility by zipper-interacting protein kinase.
TLDR
Future investigations of ZIPK function in smooth muscle will undoubtably focus on determining the mechanisms that regulate its cellular activity, including the identification of upstream signaling pathways, the characterization of autoinhibitory domains and regulatory phosphorylation sites, and the development of specific inhibitor compounds. Expand
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References

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TLDR
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TLDR
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TLDR
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TLDR
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