Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluRl, in transfected CHO cells

@article{Aramori1992SignalTA,
  title={Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluRl, in transfected CHO cells},
  author={Ichiro Aramori and Shigetada Nakanishi},
  journal={Neuron},
  year={1992},
  volume={8},
  pages={757-765}
}
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The hypothesis that 1S,3R- ACPD-stimulated increases in cAMP accumulation in rat hippocampal slices are dependent upon the presence of endogenous adenosine and are mediated by an mGluR that potentiates cAMP responses to other agonists is tested.
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Group I metabotropic glutamate receptors, mGlu1a and mGlu5a, couple to cyclic AMP response element binding protein (CREB) through a common Ca2+‐ and protein kinase C‐dependent pathway
TLDR
Although the [Ca2+]i signatures activated by these mGlu receptors differ, they couple to CREB with comparable potency and recruit similar downstream components to execute CREB phosphorylation, indicating that coupling of the group I mGLU receptors to CREBs occurs independently of these pathways.
Regulation of mitogen-activated protein kinases by Group I metabotropic glutamate receptors
TLDR
Stimulation of mGlula/mGlu5a receptors, did not alter cellular proliferation, or have a marked effect on cytoskeletal organisation, as measured by immunocytochemistry, indicating that the activation of mitogenic signalling by these two mGlu receptors does not result in changes in growth in these cells.
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