Signal transduction and genes-to-behaviors pathways in psychiatric diseases.

  title={Signal transduction and genes-to-behaviors pathways in psychiatric diseases.},
  author={Husseini K. Manji and Irving I Gottesman and Todd D. Gould},
  journal={Science's STKE : signal transduction knowledge environment},
  volume={2003 207},
Although psychiatric diseases are among the most common and destructive of all human illnesses, the molecular and cellular mechanisms underlying their complex origins remain to be elucidated. Dysfunction of critical intracellular signaling pathways is very likely to be involved. This conclusion is based on a number of observations, including the short- and long-term cellular effects of psychiatric drugs; the critical role signaling pathways play in neurotransmitter, neuropeptide, and… CONTINUE READING


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