Signal transduction and gene control: the cAMP pathway.

  title={Signal transduction and gene control: the cAMP pathway.},
  author={E Borrelli and Jean Pierre Montmayeur and Nicholas Simon Foulkes and Paolo Sassone-Corsi},
  journal={Critical reviews in oncogenesis},
  volume={3 4},
The transcriptional activity of a gene can be regulated by a multitude of trans-acting factors that interact with specific cis-acting elements, mostly located in the promoter regions. The function of transcription factors is modulated by intracellular signal transduction pathways, which are activated by specific ligands binding to the appropriate membrane receptors. Here we discuss the links between the activation of the adenylyl cyclase pathway and the transcriptional response of cAMP… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 48 extracted citations

Elucidating biological risk factors in suicide: Role of protein kinase A

Progress in Neuro-Psychopharmacology and Biological Psychiatry • 2011
View 6 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…