Corpus ID: 27373471

Signal transduction and biochemical targeting of ovarian carcinoma.

  title={Signal transduction and biochemical targeting of ovarian carcinoma.},
  author={George Weber and Dao-fu Shen and Wenping Li and H Yang and Katherine Y. Look and Margit Abonyi and No{\'e}mi Prajda},
  journal={European journal of gynaecological oncology},
  volume={21 3},
UNLABELLED The purpose was to identify novel targets for the chemotherapy of ovarian carcinoma. METHODS Assays were worked out to measure the activities of P1 kinase, PIP kinase and PLC in ovarian carcinoma samples and in OVCAR-5 cells and to compare the activities to those in normal ovaries. A method was also designed for measuring the concentration of the end product of signal transduction, IP3. RESULTS AND DISCUSSION Signal transduction activity was markedly increased in ovarian cancer… Expand
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