Corpus ID: 27373471

Signal transduction and biochemical targeting of ovarian carcinoma.

@article{Weber2000SignalTA,
  title={Signal transduction and biochemical targeting of ovarian carcinoma.},
  author={George Weber and Dao-fu Shen and Wenping Li and H Yang and Katherine Y. Look and Margit Abonyi and No{\'e}mi Prajda},
  journal={European journal of gynaecological oncology},
  year={2000},
  volume={21 3},
  pages={
          231-6
        }
}
UNLABELLED The purpose was to identify novel targets for the chemotherapy of ovarian carcinoma. METHODS Assays were worked out to measure the activities of P1 kinase, PIP kinase and PLC in ovarian carcinoma samples and in OVCAR-5 cells and to compare the activities to those in normal ovaries. A method was also designed for measuring the concentration of the end product of signal transduction, IP3. RESULTS AND DISCUSSION Signal transduction activity was markedly increased in ovarian cancer… Expand
Oncogenic pathways implicated in ovarian epithelial cancer.
TLDR
It can be predicted with confidence that the discovery of potent inhibitors of signal transduction and the development of discovery tools, such as proteomics and metabolomics, may change the way by which clinicians may now address basic biomedical questions in this insidious and lethal disease. Expand
Ribavirin acts via multiple pathways in inhibition of leukemic cell proliferation.
TLDR
Ribavirin is a potent anticancer agent, being a strong inducer of apoptosis and a moderate inducers of differentiation in K562 cells, mediated through the modulation of key molecular and metabolic pathways. Expand
Inhibitory effect of genistein and daidzein on ovarian cancer cell growth.
TLDR
An inhibitory effect of genistein is demonstrated on ovarian cancer cell growth and colony size by determining caspase-3 activity. Expand
Therapeutic potential of phosphoinositide 3-kinase inhibitors
TLDR
The progress in the development of PI 3-K inhibitors and their potential applications in medicine are summarised and the opportunities and concerns inherent in targeting this essential signalling pathway are discussed. Expand
Anticancer therapeutic potential of soy isoflavone, genistein.
TLDR
Althoughgenistein has many potentially therapeutic actions against cancer, its biphasic bioactivity requires caution in determining therapeutic doses of genistein alone or in combination with chemotherapy, radiation therapy, and/or immunotherapies. Expand
Basic Studies on Chemopreventive Properties of Quercetin and Curcumin and Other Plant-origin Compounds in Ovarian Cancer Cells-A Mini-review
TLDR
Results provide limited support for an association between nonisoflavone flavonoids intake and ovarian cancer risk, therefore there is a need for further and more accurate studies to be confirmed. Expand
Establishment of intraperitoneal transplantation model of cisplatin-resistant ovarian carcinoma cell in scid mice
TLDR
An intraperitoneal transplantation model of human ovarian carcinoma SKOV3/CDDP cell in severe combined immunodeficiency (SCID) mouse and its biologic characteristics are developed. Expand