Signal transduction: evolution of an idea.

@article{Rodbell1995SignalTE,
  title={Signal transduction: evolution of an idea.},
  author={Martin Rodbell},
  journal={Environmental Health Perspectives},
  year={1995},
  volume={103},
  pages={338 - 345}
}
  • M. Rodbell
  • Published 1 April 1995
  • Computer Science
  • Environmental Health Perspectives
Abstract“In general there is no set of observations conceivable which can give enough information about the past of a system to give complete information as to its future”: Norbert Wiener. “Think simplicity; then discard it”: Alfred North Whitehead 

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...

References

SHOWING 1-10 OF 83 REFERENCES

Allosteric proteins and cellular control systems.

G-Proteins Have Properties of Multimeric Proteins: An Explanation for the Role of GTPases in their Dynamic Behavior

The possible structural organization of surface membrane receptors, heterotrimeric GTP-binding regulatory proteins (G-proteins), and effectors (adenylyl cyclase, phospholipases, phosphodiesterases,

The regulatory component of adenylate cyclase. Purification and properties.

The disaggregation theory of signal transduction revisited: further evidence that G proteins are multimeric and disaggregate to monomers when activated.

  • S. JahangeerM. Rodbell
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1993
It is concluded that the multimeric structures of G proteins in brain membranes are at least partially preserved in digitonin and that activation of these structures in membranes yields monomers of G protein rather than the disaggregated products observed in Lubrol.

Inositol trisphosphate, a novel second messenger in cellular signal transduction

Diacylglycerol operates within the plane of the membrane to activate protein kinase C, whereas inositol trisphosphate is released into the cytoplasm to function as a second messenger for mobilizing intracellular calcium.

Molecular mechanism of GTP hydrolysis by bovine transducin: pre-steady-state kinetic analyses.

The pre-steady-state kinetics of GTP hydrolysis by T was studied by rapid quenching and filtration techniques in a reconstituted system containing purified R* and T and indicated that the burst represents the fast hydrolyzing of G TP at the binding site of T, which results in the accumulation of T-GDP.

The regulatory GTPase cycle of turkey erythrocyte adenylate cyclase.

Values of hormone stimulated adenylate cyclase and GTPase activities similar to those determined by direct measurements were found, and were in good agreement with those determined directly.
...