Signal transduction: evolution of an idea.

  title={Signal transduction: evolution of an idea.},
  author={Martin Rodbell},
  journal={Environmental Health Perspectives},
  pages={338 - 345}
  • M. Rodbell
  • Published 1 April 1995
  • Computer Science
  • Environmental Health Perspectives
Abstract“In general there is no set of observations conceivable which can give enough information about the past of a system to give complete information as to its future”: Norbert Wiener. “Think simplicity; then discard it”: Alfred North Whitehead 

Living is Information Processing: From Molecules to Global Systems

The innovation reported here is essentially to integrate ideas, basing information on the ‘general definition of information’, rather than simply the statistics of information, thereby explaining how functional information operates throughout life.

Signal transduction via G protein coupled receptors: a personal outlook

  • W. Schlegel
  • Biology
    Journal of receptor and signal transduction research
  • 2010
Seven fundamental concepts governing signal transduction via G protein coupled receptors are recalled and it appears very likely that these complexes are highly organized in situ; how such organization is achieved remains puzzling, and an important question to be answered.

Regulation of G protein-initiated signal transduction in yeast: paradigms and principles.

This review describes the signal transduction pathway used by budding yeast to respond to its peptide mating pheromones, comprised by receptors, a heterotrimeric G protein, and a protein kinase cascade all remarkably similar to counterparts in multicellular organisms.

Biophysical Chemistry of Signal Transduction

Biological communication based on chemical signal transduction “is a complex meshwork of transduction structures in which GTP-binding proteins, cell-surface receptors, the extracellular matrix and the vast cytoskeletal network are joined in a community of effort …”.

Introduction to the series on novel aspects of cardiovascular G-protein-coupled receptor signaling.

The initial concept of drugs acting on receptors is generally credited to John Newport Langley and his pioneering work on the antagonistic effects of atropine, but based on Dale's experiments on the physiological effect of Ergot preparations, the concept evolved that there were two classes of adrenotropic receptors: those whoseaction results in excitation and those whose action results in inhibition of the effector cells.

The Social as Signal in the Body of Chromatin

This article recounts the history of how hormone biologists came to think in terms of signal transduction in the late 1960s and why this cybernetic legacy is important for understanding the ‘environmental turn’ of epigenetics.

Synaptic vesicle cycle, dendritic spines and signal transduction

This review is a collection summary of key information from the recent literature describing the molecular and functional aspects of the cycle of synaptic vesicle, the composition of postsynaptic density, dendritic spines, and signal transduction.



Allosteric proteins and cellular control systems.

G-Proteins Have Properties of Multimeric Proteins: An Explanation for the Role of GTPases in their Dynamic Behavior

The possible structural organization of surface membrane receptors, heterotrimeric GTP-binding regulatory proteins (G-proteins), and effectors (adenylyl cyclase, phospholipases, phosphodiesterases,

The regulatory component of adenylate cyclase. Purification and properties.

The disaggregation theory of signal transduction revisited: further evidence that G proteins are multimeric and disaggregate to monomers when activated.

  • S. JahangeerM. Rodbell
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1993
It is concluded that the multimeric structures of G proteins in brain membranes are at least partially preserved in digitonin and that activation of these structures in membranes yields monomers of G protein rather than the disaggregated products observed in Lubrol.

Inositol trisphosphate, a novel second messenger in cellular signal transduction

Diacylglycerol operates within the plane of the membrane to activate protein kinase C, whereas inositol trisphosphate is released into the cytoplasm to function as a second messenger for mobilizing intracellular calcium.

Molecular mechanism of GTP hydrolysis by bovine transducin: pre-steady-state kinetic analyses.

The pre-steady-state kinetics of GTP hydrolysis by T was studied by rapid quenching and filtration techniques in a reconstituted system containing purified R* and T and indicated that the burst represents the fast hydrolyzing of G TP at the binding site of T, which results in the accumulation of T-GDP.

The regulatory GTPase cycle of turkey erythrocyte adenylate cyclase.

Values of hormone stimulated adenylate cyclase and GTPase activities similar to those determined by direct measurements were found, and were in good agreement with those determined directly.