Signal transduction: Thumbs up for inactivation

  title={Signal transduction: Thumbs up for inactivation},
  author={Holger Rehmann and J. L. Bos},
variety of cellular processes — ranging from proliferation to adhesion — in response to information received at the cell surface. These proteins, which are part of a broader class known as G proteins, are in essence simple on/off switches. Whether they are on or off is determined by the small molecules to which they bind: they are on when bound to guanine nucleotide triphosphate (GTP), and off when bound to guanine nucleotide diphosphate (GDP). The switch is flicked on by guanine… CONTINUE READING