Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells

@article{Sargiacomo1993SignalTM,
  title={Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells},
  author={Massimo Sargiacomo and Marius Sudol and Zhao Lan Tang and Michael Phillip Lisanti},
  journal={The Journal of Cell Biology},
  year={1993},
  volume={122},
  pages={789 - 807}
}
GPI-linked protein molecules become Triton-insoluble during polarized sorting to the apical cell surface of epithelial cells. These insoluble complexes, enriched in cholesterol, glycolipids, and GPI-linked proteins, have been isolated by flotation on sucrose density gradients and are thought to contain the putative GPI-sorting machinery. As the cellular origin and molecular protein components of this complex remain unknown, we have begun to characterize these low-density insoluble complexes… CONTINUE READING
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