Signal transducers and activators of transcription 3 signaling pathway: an essential mediator of inflammatory bowel disease and other forms of intestinal inflammation.

@article{Musso2005SignalTA,
  title={Signal transducers and activators of transcription 3 signaling pathway: an essential mediator of inflammatory bowel disease and other forms of intestinal inflammation.},
  author={Alessandro Musso and Patrizia Dentelli and Alessandra Carlino and Luigi Chiusa and Alessandro Repici and Andreas Sturm and Claudio Fiocchi and Mario Rizzetto and Luigi Pegoraro and Carla Sategna-Guidetti and Maria Felice Brizzi},
  journal={Inflammatory bowel diseases},
  year={2005},
  volume={11 2},
  pages={
          91-8
        }
}
Crohn's disease (CD) and ulcerative colitis (UC), the two major forms of chronic inflammatory bowel disease (IBD), are characterized by mucosal immune cell activation that is driven by a cytokine imbalance. Several cytokines involved in IBD act through the activation of the signal transducers and activators of transcription (STAT) family. We investigated the activation of STAT3 in the mucosa of CD and UC patients, and evaluated whether this event is specific for IBD patients. Using… CONTINUE READING

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