Signal transducers and activators of transcription-3/pim1 axis plays a critical role in the pathogenesis of human pulmonary arterial hypertension.

@article{Paulin2011SignalTA,
  title={Signal transducers and activators of transcription-3/pim1 axis plays a critical role in the pathogenesis of human pulmonary arterial hypertension.},
  author={Roxane Paulin and Audrey Courboulin and Jolyane Meloche and Vincent Mainguy and Eric Dumas de la Roque and Nehm{\'e} Saksouk and Jacques C{\^o}t{\'e} and Steeve Provencher and Mark A Sussman and S{\'e}bastien Bonnet},
  journal={Circulation},
  year={2011},
  volume={123 11},
  pages={1205-15}
}
BACKGROUND Pulmonary artery hypertension (PAH) is a proliferative disorder associated with enhanced pulmonary artery smooth muscle cell proliferation and suppressed apoptosis. The sustainability of this phenotype required the activation of a prosurvival transcription factor like signal transducers and activators of transcription-3 (STAT3) and nuclear factor of activated T cell (NFAT). Because these factors are implicated in several physiological processes, their inhibition in PAH patients could… CONTINUE READING
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